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Improper treatment of vitamin B 12 -dependent megaloblastic anemia with high-dose supplemental folic acid can potentially delay the diagnosis of vitamin B 12 deficiency and thus leave the individual at risk of developing irreversible brain and nervous system damage

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Two agents deserve serious attention here: Pentosan Polysulfate Sodium (PPS) - inhibits NF-B, suppresses TNF- and IL-6 simultaneously, inhibits cartilage-degrading enzymes, and uniquely *strengthens* cartilage matrix through increased structural cross-linking

[DOI] [PubMed] [Google Scholar] 15.Cerovecki T, Bojanic I, Brcic L, Radic B, Vukoja I, Seiwerth S, et al